NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

topical wound spray HP802-247
A cell-based combination product consisting of a fibrinogen solution and a cell preparation containing allogeneic non-proliferating, living human skin-derived keratinocytes and fibroblasts, suspended in thrombin, with potential topical wound healing enhancing and topical anti-ulcer activity. Upon sequential spray of the two components of HP802-247 topically, a thin fibrin matrix is formed on the wound surface and the cellular components are capable of secreting wound healing cytokines and growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), granulocyte-macrophage colony-stimulating growth factor (GM-CSF) and keratinocyte growth factor. Cell concentration and keratinocyte-to-fibroblast ratio in HP802-247 are essential for optimal growth factor production and thus the efficacy of this agent. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:allogeneic keratinocyte/fibroblast topical spray HP802-247
Code name:HP802247