Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

topoisomerase I/II inhibitor NEV-801

A multi-targeted agent with potential antineoplastic activity. Upon administration, NEV-801 appears to selectively inhibit topoisomerase (Topo) I and II, and activates hypoxia-inducible factor 1 (HIF-1) transcription and the expression of vascular endothelial growth factor (VEGF) mRNA. NEV-801 is also able to overcome multidrug resistance (MDR) 1-mediated resistance.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:TopI/II NEV-801
Code name:NEV-801
NEV801
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search