NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

tozasertib lactate
The lactate salt of tozasertib, a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:Aurora kinase inhibitor MK-0457
Code name:MK-0457
Chemical structure:
  • N-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2- yl]sulfanyl]phenyl]cyclopropanecarboxamide (2S)-2-hydroxypropanoate
  • propanoic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5- methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide