trabectedin
View Patient InformationA tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinate with potential antineoplastic activity. Binding to the minor groove of DNA, trabectedin inteferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks.and blocks the cell cycle in the G2 phase.
| Synonym: | ecteinascidin |
|---|---|
| US brand name: | Yondelis |
| Foreign brand name: | Yondelis |
| Abbreviation: | ET 743 |
| NSC code: | 648766 |