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triapine

A synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro.
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Synonym:3-AP
Abbreviation:3-Apct
Code name:OCX-191
OCX191
PAN-811
Chemical structure:3-aminopyridine-2-carboxaldehyde thiosemicarbazone
IND number:68338
NSC code:663249
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