NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- uridine triacetate
An orally bioavailable, lipophilic, triacetate prodrug form of the pyrimidine nucleoside, uridine, that can be used for uridine replacement or as an antidote for 5-fluorouracil (5-FU)-induced toxicity. Upon administration, uridine triacetate is deacetylated by esterases to produce uridine and acetate. In turn, uridine is converted to uridine triphosphate (UTP), which competes with fluorouridine triphosphate (FUTP), one of the toxic metabolites of 5-FU, for incorporation into RNA of normal cells. This prevents disruption of RNA synthesis in normal cells and limits toxicity resulting from overdose of 5-FU and 5-FU prodrugs. The FUTP-mediated damage to RNA is the main cause of 5-FU toxicities. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand name: Vistogard Abbreviation: TAU Code name: PN401