NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Zyflo
Chemical structure:
  • (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea
  • N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea