NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

valproic acid
A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)

Valproate Sodium
US brand name:Depacon
Foreign brand name:Alti-Valproic
Chemical structure:
  • 2-Propylpentanoic Acid
  • 2-Propylvaleric Acid
  • Di-n-propylacetic Acid