NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic leukemia. Check for active clinical trials using this agent. (NCI Thesaurus)

Code name:SGN-40
Chemical structure:
  • immunoglobulin G1, anti-(human CD40 (antigen)) (human-mouse monoclonal SGN-40 γ1-chain), disulfide with human-mouse monoclonal SGN-40 κ-chain, dimer
  • immunoglobulin G1, anti-[human tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40)] humanized mouse monoclonal SGN-40 [Glu353,Met355]γ1 heavy chain (217-219')-disulfide with κ light chain (223-223'':226-226'')-bisdisulfide dimer