NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Lopurin
Foreign brand name:Sigapurol
Chemical structure:
  • 1,5-dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one
  • 1H-pyrazolo[3,4-d]pyrimidin-4-ol
  • 4-hydroxypyrazolo[3,4-d]pyrimidine