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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:methylglyoxal bisguanylhydrazone
mitoguazone dihydrochloride
pyruvaldehyde bis(amidinohydrazone)
Foreign brand name:Zyrkamine
Code name:DRG-0223
NSC 32946
Chemical structure:
  • 1,1'-[(methylethanediylidene)dinitrilo)diguanidine
  • 2,2"-(methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide]
  • methylglyoxal bis(amidinohydrazone)