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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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zorubicin hydrochloride
A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:benzoyl hydrazone daunorubicin
daunorubicin benzoylhydrazone hydrochloride
rubidazone
Foreign brand name:Zorubicine
Abbreviation:RBZ
Code name:RP-22050
Chemical structure:
  • (2S-cis)-benzoic acid[1-[4-[3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3-naphthacenyl]ethylidene]hydrazide
  • benzoic acid hydrazide 3-hydrazone with daunorubicin