NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:medroxyprogesterone acetate
US brand name:Curretab
Provera Dosepak
Chemical structure:
  • (6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione
  • 17alpha-hydroxy-6alpha-methylprogesterone
  • 6alpha-methyl-17alpha-hydroxyprogesterone
  • 6alpha-methyl-4-pregnen-17alpha-ol-3,20-dione