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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. Check for active clinical trials using this agent. (NCI Thesaurus)

Deoxyspergualin Hydrochloride
Gusperimus Trihydrochloride
Foreign brand name:Spanidin
Code name:BMS-181173
Chemical structure:
  • 15-deoxyspergualin hydrochloride
  • 1-amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione
  • 7-{(aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamide
  • N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamide