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chloroquinoxaline sulfonamide

A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner.
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Synonym:chlorosulfaquinoxaline
chlorsulfaquinoxaline
Abbreviation:CQS
Chemical structure:benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-
IND number:32123
NSC code:339004
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