NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A synthetic, broad-spectrum tetracycline with antimicrobial activity. Doxycycline binds reversibly to the 30S ribosomal subunit and possibly to the 50S ribosomal subunit, blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex, which results in an inhibition of bacterial protein synthesis. In addition, this agent may inhibit collagenase activity. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:Doxycycline Monohydrate
US brand name:Vibramycin