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NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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temoporfin
A synthetic light-activated chlorin with photodynamic activity. Upon systemic administration, temoporfin distributes throughout the body and is taken up by tumor cells. Upon stimulation of temoporfin by non-thermal laser light (at 652 nm), and in the presence of oxygen, this agent produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to tumor cells. This may kill tumor cells and may reduce the tumor size. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:m-tetrahydroxyphenyl-chlorin
Foreign brand name:Foscan
Abbreviation:mTHPC
Chemical structure:
  • 5,10,15,20-tetra-(m-hydroxyphenyl)chlorin
  • meta-tetrahydroxyphenyl chlorin
  • meta-tetrahydroxyphenylchlorin