NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

teglarinad chloride
A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:apoptosis inducer GMX1777
Code name:GMX1777
Chemical structure:
  • 4-({N-[6-(4-chlorophenoxy)hexyl]-N'-cyanocarbamimidoyl}amino)-1-(3-oxo- 2,4,7,10,13,16-hexaoxaheptadecan-1-yl)pyridinium chloride
  • pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino) methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-, chloride