NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

ioflubenzamide I-131
An iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of ioflubenzamide I-131 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas. Check for active clinical trials using this agent. (NCI Thesaurus)

iodine I 131 MIP-1145
Chemical structure:N-(4-(2-(diethylamino)ethylcarbamoyl)-2-iodo-5-methoxyphenyl)benzo[d][1,3]dioxole-5 carboxamide; N-(2-diethylamino-ethyl)-4-(4-F-benzamido)-5-iodo-2-methoxy-benzamide