NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

menadione topical lotion
A topical lotion containing the small organic molecule protein tyrosine phosphatase (PTP) inhibitor menadione (vitamin K3) with potential EGFR- and ErbB2/HER2-activating activities. Upon topical administration, menadione binds to and inhibits the activity of PTPs that dephosphorylate and inactivate EGFR and ErbB2 in human keratinocytes; local reversal of EGFR and ErbB2 inhibition associated with the systemic administration of EGFR inhibitors may help alleviate EGFR inhibitor-mediated skin toxicity. EGFR (epidermal growth factor receptor) and ErbB2/HER2 (erythroblastic leukemia viral oncogene homolog 2/ human epidermal growth factor receptor 2) are cell surface receptors that are upregulated in a number of cancer cells types and play important roles in the growth and maintenance of normal epithelial tissues. Check for active clinical trials using this agent. (NCI Thesaurus)