NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

tiotropium bromide monohydrate
The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Spiriva
Chemical structure:
  • 1,4-Dihydro-3,5-Diiodo-1-Methyl-4-Oxopyridine-2,6-Dicarboxylic Acid
  • 6.Beta.,7.Beta.-Epoxy-3.Beta.-Hydroxy-8-Methyl-1.Alpha.H,5.Alpha.H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate