NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

Y-shape branched pegylated filgrastim
A long-acting, pegylated variant of filgrastim (recombinant human granulocyte colony-stimulating factor (G-CSF)) with immunomodulating activity. Similar to endogenous G-CSF, this agent binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. The modification of this version of filgrastim with the addition of a Y-shaped branch of polyethylene glycol at a specific lysine residue (Lys 17) theoretically serves to extend the half-life of the agent. Check for active clinical trials using this agent. (NCI Thesaurus)