NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Dolobid
Foreign brand name:Apo-Diflunisal
Chemical structure:
  • (1,1'-biphenyl)-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-
  • 2',4'-difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic acid