NCI Dictionary of Genetics Terms
The NCI Dictionary of Genetics Terms contains technical definitions for more than 200 terms related to genetics. These definitions were developed by the PDQ® Cancer Genetics Editorial Board to support the evidence-based, peer-reviewed PDQ cancer genetics information summaries.
- depth of coverage
- listen (... KUH-veh-rij)
- Refers to the number of times a nucleotide is read during sequencing. A greater depth of coverage can increase confidence in the final results. Deep coverage aids in differentiating sequencing errors from single nucleotide polymorphisms. This can be specifically useful when a patient has a mosaicism or when a tumor is heterogeneous for a mutation.