NCI Dictionary of Genetics Terms

The NCI Dictionary of Genetics Terms contains technical definitions for more than 200 terms related to genetics. These definitions were developed by the PDQ® Cancer Genetics Editorial Board to support the evidence-based, peer-reviewed PDQ cancer genetics information summaries.

unclassified variant
(un-KLA-sih-fide VAYR-ee-unt)
A variation in a genetic sequence for which the association with disease risk is unclear. Also called variant of uncertain significance, variant of unknown significance, and VUS.