NCI Dictionary of Genetics Terms

The NCI Dictionary of Genetics Terms contains technical definitions for more than 200 terms related to genetics. These definitions were developed by the PDQ® Cancer Genetics Editorial Board to support the evidence-based, peer-reviewed PDQ cancer genetics information summaries.

variant of unknown significance
(VAYR-ee-unt … UN-none sig-NIH-fih-kunts)
A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of uncertain significance, and VUS.