RAS Target Identification at FNLCR
The RAS Initiative at the Frederick National Laboratory for Cancer Research (FNLCR) is using cutting edge technologies to better define RAS proteins, complexes of RAS proteins with effector and regulatory partners, cell surface proteins that are enriched in cancer cells driven by mutant RAS, and pathways that are essential to cancer cells but not normal cells.
Attacking cancers caused by mutant RAS requires proteins, DNAs, and cell lines prepared by this group.
RAS Structural Biology
This group aims to provide structural insights into oncogenic mutants of RAS, RAS-effector, and RAS-interactor complexes.
RAS Biochemistry and Biophysics
Signaling by RAS proteins is regulated by the interactions with substrates, protein partners, and membranes that are investigated by this lab.
This lab group develops tools to track and analyze “big data” from the RAS Initiative and the larger RAS community.
RAS Cell Surfaces
The goal of this group includes identifying proteins that are enriched or unique to the surfaces of cancer cells driven by mutant RAS genes.