A drug used with other drugs to treat acute myelogenous leukemia (AML). It is also being studied in the treatment of other types of cancer. Idarubicin hydrochloride blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. It is a type of anthracycline antibiotic and a type of topoisomerase inhibitor. Also called 4-demethoxydaunorubicin and Idamycin PFS.