A drug used to treat hypercalcemia (high blood levels of calcium) caused by cancer. It is also used with other anticancer drugs to treat multiple myeloma and cancers that have spread to the bone. It is also being studied in the treatment of other types of cancer. Zoledronate may help keep bone from breaking down and prevent the loss of calcium from the bones. It is a type of bisphosphonate. Also called zoledronic acid and Zometa.