As it relates to tobacco use, a device that has a mouthpiece at one end of a tube and a small bowl at the other end that is filled with tobacco, which is lit and smoked. The smoke from a pipe is usually not inhaled into the lungs. It contains nicotine and many cancer-causing chemicals that are harmful to both smokers and nonsmokers. Pipe smoking can lead to nicotine addiction and can cause cancers of the mouth, larynx (voice box), esophagus, lung, pancreas, and bladder. It can also cause heart disease, lung disease, and other health problems.