Clinical Trials for Complementary or Alternative Medicine Procedure(s)

Trials 1-25 of 67
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  • Acupuncture for the Improvement of Cognitive Difficulties in Cancer Survivors, the CLARITY Study

    This phase II trial studies how well acupuncture works in improving cognitive difficulties in cancer survivors. Some treatments used for cancer can cause long-term side effects, such as cognitive difficulties. Acupuncture is a medical technique that involves insertion of very thin needles into specific areas on the body with the goal of promoting health and well-being. It has been widely used to treat pain, but researchers think acupuncture may help improve the cognitive difficulties and insomnia that many cancer survivors report following chemotherapy and other cancer treatments.
    Location: 6 locations

  • Managing Pain Caused by Chemotherapy in People with Myeloma or Lymphoma, OPTIMAL-HiChemo Study

    This phase III trial compares the effect of the combination of acupuncture therapy and opioids versus opioids only (usual care) for the treatment of pain in multiple myeloma and lymphoma patients who are undergoing high-dose chemotherapy. Cancer treatments can cause side effects, and one of the major side effects is pain. Treatment for severe pain usually involves opioid medications, but they may cause other side effects. Acupuncture therapy involves the insertion of very fine needles into certain points on the body and leaving them in place for about 20 minutes. Adding acupuncture therapy to the usual approach may prevent or reduce the pain caused by cancer treatments, and in turn reduce the need for opioid drugs and improve pain management in patients with multiple myeloma or lymphoma.
    Location: 2 locations

  • Ivermectin, Camostat Mesilate, Artemisia Annua, and Artesunate for the Treatment of High Risk COVID19 Infection

    This phase II trial studies the effect of ivermectin, camostat mesilate, artemisia annua, and artesunate in treating patients with coronavirus disease 2019 (COVID-19) infection who have higher risk of worsening infection. Ivermectin is a drug that may prevent virus from multiplying. Camostat mesilate may prevent viral infection and growth by blocking some of the enzymes needed by the virus to enter the body cells. Artemisia annua is a botanical plant that may prevent viral growth. Artesunate is a drug extracted from artemisia annua plant that may prevent viral growth. Giving ivermectin, camostat mesilate, Artemisia annua, or artesunate may help decrease COVID-19 virus in the body and ultimately help decrease the chance of clinical symptoms getting worse from COVID-19 and prevent hospitalization.
    Location: University of Kentucky / Markey Cancer Center, Lexington, Kentucky

  • Amplitude-Modulated Electromagnetic Fields and Regorafenib as Second-Line Therapy for the Treatment of Patients with Advanced Hepatocellular Carcinoma

    This phase II trial studies the effects of amplitude-modulated electromagnetic fields and regorafenib as second-line therapy for the treatment of patients with hepatocellular carcinoma that has spread to other places in the body (advanced), and who have received any first line systemic therapy, either standard of care sorafenib or lenvatinib, or any experimental therapy. Amplitude-modulated electromagnetic fields may interfere with the growth of tumor cells by directing radio waves at the tumor. Regorafenib interferes with the growth of tumor cells. Giving amplitude-modulated electromagnetic fields and regorafenib may kill more cancer cells.
    Location: Wake Forest University Health Sciences, Winston-Salem, North Carolina

  • Auricular Point Acupressure for the Treatment of Aromatase Inhibitor Musculoskeletal Symptoms in Breast Cancer Survivors

    This early phase I trial studies how well auricular point acupressure therapy works in treating aromatase inhibitor musculoskeletal symptoms in breast cancer survivors. Auricular point acupressure stimulates specific points on the ear to provide quick pain relief. Auricular point acupressure may help reduce the side effects of aromatase inhibitor treatment while avoiding additional side effects.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • African American Families Fighting Parental Cancer Together

    The purpose of this study is to test the usefulness of a family-based program for African American parents / primary caregivers with newly diagnosed solid tumor cancer and their adolescent children. The program is designed to promote family communication reduce and depressive symptoms for adolescence.
    Location: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

  • Acupuncture in Treating Dry Mouth Caused by Radiation Therapy in Patients with Head and Neck Cancer

    This randomized phase III trial studies acupuncture to see how well it works compared to sham acupuncture or standard therapy in treating dry mouth caused by radiation therapy (xerostomia) in patients with head and neck cancer. Acupuncture may help relieve dry mouth caused by radiation therapy.
    Location: 31 locations

  • Effectiveness of Acupuncture versus Massage for Pain and Related Symptoms in Patients with Advanced Cancer, IMPACT Study

    This phase II trial compares the long-term effectiveness of acupuncture versus massage for the treatment of pain in patients with cancer that has spread to other places in the body (advanced). Pain is one of the most commonly reported symptoms among individuals with advanced cancer, and it has been linked to other symptoms, such as tiredness (fatigue), trouble sleeping (sleep disturbances), and a decrease in quality of life. Acupuncture is a traditional Chinese medicine that involves penetrating the skin with very thin, solid, metallic needles that are moved by hand or by electrical stimulation, which may cause the brain to produce chemicals that provide pain relief. Massage therapy techniques promote joint flexibility, relieve muscular tension, and improve range of motion, which may reduce pain in targeted areas. The study will test how the two approaches compare in helping people with pain and its related symptoms and improving quality of life.
    Location: 8 locations

  • Acupuncture and Pain Counseling in Reducing Pain and Symptom Distress in Hospitalized Cancer Patients

    This trial studies how well acupuncture and pain counseling work in reducing pain and symptoms distress in hospitalized patients with cancer. Acupuncture uses thin needles placed along specific points to reduce pain. Pain counselling may be an effective method to help patients learn about pain management. Non-pharmacologic approaches such as acupuncture and pain counseling may broaden pain management options to help in providing comprehensive care for diverse patients with cancer.
    Location: 4 locations

  • Mindfulness Education in Reducing Active Surveillance Stress in Participants with Prostate Cancer and Their Spouses

    This trial studies how well mindfulness education works in reducing surveillance stress in participants with prostate cancer and their spouses. Mindfulness education may help to reduce the effects of active surveillance stress, uncertainty, and rumination.
    Location: 4 locations

  • Duloxetine and Neurofeedback Training for the Treatment of Chemotherapy Induced Peripheral Neuropathy

    This phase II trial investigates how well duloxetine and neurofeedback training work in treating patients with chemotherapy induced peripheral neuropathy. Duloxetine is a type of serotonin and norepinephrine reuptake inhibitor that increases the amount of certain chemicals in the brain that help relieve depression and peripheral neuropathy. Neurofeedback training is a type of therapy that uses an electroencephalograph (EEG) and a computer software program to measure brain wave activity and may help teach patients with peripheral neuropathy (nerve damage) how to change their own brain waves to lower their feelings of neuropathy and help improve their overall quality of life. Giving duloxetine and neurofeedback training may work better in treating peripheral neuropathy caused by chemotherapy compared to duloxetine or neurofeedback training alone.
    Location: 2 locations

  • Video-Conferenced Stress Management and Relaxation Training for the Improvement of Influenza Vaccine Response and Quality of Life in Older Patients with Stage 0-III Breast Cancer, the VSMART Trial

    This trial studies how well a home-based group stress management program called remotely-delivered Cognitive Behavioral Stress Management (R-CBSM) works in improving response to the influenza (flu) vaccine and quality of life in older patients with stage 0-III breast cancer undergoing treatment. R-CBSM is a type of stress management and relaxation training provided through video-conferencing. Women with breast cancer often experience a lot of stress. Stress can also affect how the immune system works. Because treatment for breast cancer can also affect the immune system, the extra effect of stress along with cancer treatment may make patients more vulnerable to things like the flu virus. This can get worse with age. It is critical for older women getting treatment for breast cancer to get help from the flu vaccine. Stress can reduce the body's positive response to the flu vaccine, even in healthy people. Participating in R-CBSM may reduce stress and improve flu vaccine response and general quality of life. It is not yet known whether having the stress management program before the vaccine has different effects on immune response to the influenza vaccine and quality of life than having it after the vaccine in older breast cancer patients undergoing treatment.
    Location: 2 locations

  • Mindfulness-Music Intervention in Reducing Anxiety and Stress in Adolescents and Young Adults Receiving Cancer Treatment

    This trial studies how well a mindfulness-music intervention works in reducing anxiety and stress in adolescents and young adults receiving cancer treatment. A program designed to incorporate music-based meditation practices and music making activities (e.g., guitar, drums) may help to promote relaxation during cancer treatment.
    Location: 2 locations

  • Pain Management Support Study for Patients With Advanced Cancer

    Chronic pain is one of the most feared symptoms in people with cancer. Insufficient relief from pharmacological treatments and the fear of side effects are important reasons for the growing use of complementary pain management approaches in cancer care. On such approach is music therapy. Although several studies have demonstrated that music therapy interventions can reduce pain in people with cancer, few studies have examined the therapeutic mechanisms that explain how music therapy interventions lead to improved pain management. The purpose of this study is to examine whether an interactive music therapy intervention improves psychological and social factors that play an important role in chronic pain management in people with advanced cancer. The findings will contribute towards the optimization of music therapy for palliation of chronic pain in people with advanced cancer.
    Location: 2 locations

  • Acupuncture for the Treatment of Cancer-Related Cognitive Difficulties in Stage 0-III Breast Cancer Survivors, The ENHANCE Trial

    This phase II trial studies the effect of acupuncture on cancer-related cognitive difficulties and insomnia in stage 0-III breast cancer survivors. Acupuncture is a medical technique that involves insertion of very thin needles into specific areas on the body with the goal of promoting health and well-being. It has been widely used to treat pain, but researchers think acupuncture can also improve the cognitive difficulties and insomnia that many cancer survivors report following chemotherapy and other cancer treatments. There is also some evidence that fixing sleep problems can improve some cognitive functions, such as memory and concentration. This study may provide researchers with useful information about acupuncture’s effects on both cognitive function and insomnia. The study may also give researchers better insight into the connection between insomnia and cognitive difficulties.
    Location: Memorial Sloan Kettering Cancer Center, New York, New York

  • Yoga Intervention for the Improvement of Cancer-Related Stress in Cancer Survivors

    This clinical trial develops and test a yoga intervention in improving cancer-related stress in cancer survivors. The online hatha yoga intervention of breathing and movement incorporates both restorative poses, breathing techniques, guided meditation and may reduce stress levels and improve overall quality of health in cancer survivors.
    Location: Roswell Park Cancer Institute, Buffalo, New York

  • Integrative Palliative Care / Psycho-Oncology Telehealth Intervention (Group Medical Visits) in Patients with Advanced Cancer

    This trial investigates whether a joint and integrative approach to cancer care using palliative care and psycho-oncology is possible, and if it's beneficial to patients with cancer that has spread to other places on the body (advanced). The information gained from this study may help patients to learn about the medicinal and non-medicinal strategies to cope with their symptoms and side effects of their diagnosis and treatment while receiving peer support, in addition to standard individualized medical care.
    Location: University of California San Francisco, San Francisco, California

  • A Value Affirmation Intervention in Breast Cancer Patients Taking Aromatase Inhibitors

    Aromatase inhibitors are a powerful medication for reducing the risk of recurrence and increasing survival in postmenopausal breast cancer patients. However, these medications can lead to intolerable side effects, poor medication adherence, and increased stress levels. This project's broad objective is to assess whether an intervention can improve medication adherence and reduce physical symptoms and stress in breast cancer patients prescribed aromatase inhibitors. Participants will be randomly assigned to a values affirmation or reflective journaling condition. Interventions will be writing-based, one essay per month for six months. Physical symptoms and perceived stress will be assessed at baseline, post-intervention (one month after the intervention), and follow-up (six months from the post-intervention assessment and seven months after the end of the intervention). Furthermore, an electronic pill bottle will continuously assess daily compliance so that medication adherence rates during the intervention, post-intervention, and follow-up can be calculated.
    Location: Carnegie Mellon University, Pittsburgh, Pennsylvania

  • Yoga Therapy during Chemotherapy and Radiation Treatment for the Improvement of Physical and Emotional Well-Being in Patients with Stage IB2-IIIB Cervical Cancer

    This trial studies how well yoga therapy works during chemotherapy and radiation treatment in improving physical and emotional well-being in patients with stage IB2-IIIB cervical cancer. Yoga therapy may help to balance the mind and body through exercise, meditation (focusing thoughts), and control of breathing and emotions.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Yoga Program for Improving the Quality of Life in Couples Coping with Cancer

    This clinical trial seeks to learn if a yoga program can improve physical performance, quality of life and symptom burden in cancer patients who are undergoing radiation therapy, and their partners. Taking part in yoga or stretching sessions may lower distress, improve quality of life, and / or may improve sleep and fatigue for cancer patients and their caregivers.
    Location: M D Anderson Cancer Center, Houston, Texas

  • A Distress Reduction Intervention for Patients with BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors

    This clinical trial looks at how well a distress reduction intervention, called "Being Present", works to improve the quality of life of patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs) or chronic phase chronic myeloid leukemia (CP-CML) who are taking tyrosine kinase inhibitors (TKIs) and their caregivers. Mindfulness meditation is the practice of repeatedly bringing attention back to the immediate experience and may help people cope with various types of illness, stress, and worry. This may help patients and caregivers to gradually learn to disconnect from reacting to and dwelling on the past and future and instead fully experiencing the present moment.
    Location: University of California San Francisco, San Francisco, California

  • Acupuncture for the Management of Postoperative Pain in Patients with Pancreatic or Colorectal Cancer Undergoing Surgery

    This trial investigates how well acupuncture works for the management of pain after surgery in patients having open colorectal or pancreatic surgery. Acupuncture may help to reduce postoperative symptoms including pain. This study may help researchers learn if acupuncture reduces after-surgery side effects and improves recovery.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Oral Cryotherapy plus Acupressure and Acupuncture versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy from Oxaliplatin-Based Chemotherapy in Patients with Gastrointestinal Cancer

    This phase II trial investigates how well oral cryotherapy plus acupressure and acupuncture compared with oral cryotherapy alone work in decreasing chemotherapy-induced peripheral neuropathy in patients with gastrointestinal cancer who are receiving oxaliplatin-based chemotherapy. Acupressure is the application of pressure or localized massage to specific sites on the body to control symptoms such as pain or nausea. Acupuncture is the technique of inserting thin needles through the skin at specific points on the body to control pain and other symptoms. Cryotherapy uses cold temperature such as oral ice chips to prevent abnormally increased pain sensation. Giving oral cryotherapy with acupressure and acupuncture may work better in decreasing chemotherapy-induced peripheral neuropathy from oxaliplatin-based chemotherapy in patients with gastrointestinal cancer compared to oral cryotherapy alone.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

  • Acupuncture for the Treatment of Intravesical BCG-Related Adverse Events in High-Risk Non-muscle Invasive Bladder Cancer

    This phase II trial studies the safety and feasibility of utilizing acupuncture in patients with high-risk bladder cancer that has not spread to the surrounding muscle (non-muscle invasive) undergoing treatment with intravesical BCG. BCG is a weakened form of the bacterium Mycobacterium bovis that does not cause disease. It is used in a solution to stimulate the immune system in the treatment of bladder cancer. Unfortunately, many patients experience side effects such as pelvic pain, painful urination, severe urgency, frequency, urge incontinence, need to urinate at night, and / or infectious complications. These side effects may cause patients to delay or stop BCG treatment. Acupuncture is a medical intervention in which fine metallic needles are inserted into anatomical locations of the body to stimulate the peripheral and the central nervous system. Giving acupuncture before each intravesical BCG treatment may help to reduce the side effects of intravesical BCG, and help patients complete treatment. Specific outcomes of interest include acceptability to patients, effect of acupuncture on intravesical BCG-related side effects, and adverse events associated with acupuncture.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

  • Arts and Music Therapy for the Improvement of Quality of Life in Patients with Stage 0-III Breast Cancer

    This clinical trial studies a therapist-led art or music therapy program in improving quality of life in patients with stage 0-III breast cancer. A cancer diagnosis can be a stressful experience. Many patients report dealing with anxiety, fatigue, sleep disturbances, and memory or concentration problems. The art-based and / or music-based therapy program may help patients with breast cancer achieve an improved quality of life.
    Location: Case Comprehensive Cancer Center, Cleveland, Ohio


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