| High throughput multidimensional chemoproteomics for function-directed covalent target discovery | 2025 | Keriann Marie Backus | University of California Los Angeles |
| Advanced Development of Patient Ascites Therapeutic Response Biosensors | 2025 | Jesse Samuel Boehm, Beth Cimini, Samuel J Klempner | Massachusetts Institute of Technology |
| Ultra-sensitive mass spectrometry-based immunopeptidomics using digital microfluidics | 2025 | Etienne Caron | Yale University |
| Defining Intercellular Heterogeneity in Cell Cycle Quiescence | 2025 | Jeanette Gowen Cook | University of North Carolina Chapel Hill |
| A Novel Multi-analyte Approach to Democratize Cancer Biobanking | 2025 | Brian Michael Davis, Sunil S. Badve, Yesim Gokmen Polar | GE Medical Systems Information Technologies, Inc |
| Next generation platforms for interrogating TCR specificity | 2025 | Kenan Christopher Garcia | Stanford University |
| Increasing organoid reproducibility and complexity for drug testing and disease modeling | 2025 | Zev Jordan Gartner | University of California, San Francisco |
| An enabling approach for deep metaproteomic characterization of microbial contributors to tumorigenesis in clinical samples | 2025 | Timothy J. Griffin, Ryan Coulson Hunter, Pratik D. Jagtap | University of Minnesota |
| High-throughput and multiplex single-molecule quantification and sorting of single EV | 2025 | David Aaron Issadore | University of Pennsylvania |
| Mapping Dynamic Changes in Protein Interactome using Proximity Labeling with High Temporal Resolution | 2025 | Andrei V. Karginov, Alexander Adibekian | University of Illinois at Chicago |
| Microbiome-Mediated Tumor Immunomodulation in a Pathomimetic Colorectal Cancer Chip | 2025 | Hyun Jung Kim | Cleveland Clinic |
| Precision single-cell mapping of chromatin-associated protein activity by molecular footprinting to chart disruptions to gene regulation and dissect tumor heterogeneity in cancer | 2025 | Dan Landau | Weill Medical College of Cornell University |
| Programmable nucleic acid cytometry for unraveling heterogeneity in tumors and therapies | 2025 | Caleb Andrew Lareau, Ronan Chaligne | Sloan-Kettering Institute of Cancer Research |
| Streamlining sample preparation with high throughput SpinEx (Separation processing integration for Extracellular vesicles) | 2025 | Hakho Lee | Massachusetts General Hospital |
| High-throughput single-cell joint RNA and DNA methylation mapping of Acute Myeloid Leukemia | 2025 | Sai Ma | Icahn School of Medicine at Mount Sinai |
| Charting cellular attraction-based interactome with Multivalent Adhesive Probe AFM (MAPA) | 2025 | Pawel A. Osmulski, Maria E. Gaczynska | University of Texas Health Science Center |
| Efficient, cost-effective, and ultrasensitive sequencing of somatic mutations and methylation | 2025 | Stephen J. Salipante | University of Washington |
| Sequence optimization for mRNA cancer therapy | 2025 | Georg Seelig | University of Washington |
| Red-light driven targeted degradation of cancer proteins | 2025 | Neel H. Shah, Tomislav Rovis | Columbia University New York Morningside |
| Single-cell (phospho-)proteomics platform for functional analysis of tumor microenvironment | 2025 | Tujin Shi | Battelle Pacific Northwest Laboratories |
| Enriching and Base-Resolution Profiling of 5-Methylcytosine in Degraded Clinical Samples | 2025 | Weixin Tang | University of Chicago |
| Development of Personalized Intact Proteome Map for Ovarian Cancer Patients Using Ultrasensitive Multiplexed Top-down Proteomics | 2025 | Si Wu, Anthony Wg Burgett | University of Alabama in Tuscaloosa |
| Quantification of molecular interactions across the matrix spectrum enables cancer research | 2024 | Darryl Bornhop | Vanderbilt University |
| A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis | 2024 | Fei Chen | Broad Institute |
| Bio-orthogonal Mid-infrared Photothermal Imaging of Cancer Metabolism | 2024 | Ji-Xin Cheng | Boston University |
| Spatial protein-protein interaction networks in situ by multiplexed proximity ligation | 2024 | Ahmet Coskun | Georgia Institute of Technology |
| Nano-CRISPR extracellular vesicle sensing system for longitudinal tumor monitoring | 2024 | Hyungsoon Im | Massachusetts General Hospital |
| Microphysiological platform for analyzing multiple myeloma's tumor microenvironment, enabling immunotherapy assessment and drug screening | 2024 | Tania Tali Konry | Northeastern University |
| Develop and validate demineralized bone paper-based human bone metabolic and senolytic assays | 2024 | Jungwoo Lee | University of Massachusetts Amherst |
| Precision Tumor Sampling of Melanoma Using Laser Microbiopsy | 2024 | Sapun Parekh, James Tunnell | University of Texas at Austin |
| 3D Proteomics at Single Cell Resolution with Covalent Protein Painting (CPP) | 2024 | John Yates III | Scripps Research Institute |
| Development of a Directed Evolution Platform for RNA Methyltransferases | 2024 | Huiqing Zhou, Jia Niu | Boston College |
| Multiplexed, Continuous Reporting of Gene Expression via CRISPR-mediated Transcriptional Activation | 2024 | Jeffrey Ishizuka | Yale University |
| Spatially resolved multi-omics sequencing of FFPE tissues at cellular level | 2024 | Yanxiang Deng | University of Pennsylvania |
| Evolved Molecules that Destroy Cancer Relevant Proteins | 2024 | Elisa Biondi | Foundation for Applied Molecular Evolution |
| A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state | 2024 | Robert Rostomily,
Francois St-Pierre | Methodist Hospital Research Institute, Baylor College of Medicine |
| Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq | 2024 | Paul Blainey | Broad Institute, Inc. |
| Quantitative analysis and manipulation of chromosome dynamics in cancer organoids | 2024 | Torsten Wittmann | University of California, San Francisco |
| Proximity epigenomics for context-specific analysis of complex chromatin features | 2024 | Philipp Oberdoerffer | Johns Hopkins University |
| Enabling in vivo barcoded single-cell multiomics-compatible genome-wide screens in personalized tumor models using defined-copy somatic transgenesis | 2024 | Joshua Breunig | Cedars-Sinai Medical Center |
| High Throughput Digital Droplet Assays for Ultrasensitive Multimodal (DNA, RNA, and Protein) Diagnostics | 2024 | David Issadore | University of Pennsylvania |
| An integrated functional proteomics platform for accelerated discovery of isoform-specific determinants of cancer | 2024 | Gloria Sheynkman, Stephen Yi | University of Virginia |
| Identification of cancer neoepitope-specific T cells using novel high-throughput hydrogel based platforms | 2024 | Jonathan Schneck | Johns Hopkins University |
| A Real-Time AI-Driven High-Throughput Proteomics Data Acquisition Method for Clinical Applications | 2024 | Wilhelm Haas, Lecia Sequist | Massachusetts General Hospital |
| New Chemical Tools for Covalent Drug Discovery | 2024 | Jarrod Marto, Justin Kim | Dana-Farber Cancer Institute |
| Tumor Metabolic Profiling by Multiplexed Single-Cell Lipid and mRNA Imaging | 2024 | Sarah Heilshorn | Stanford University |
| Bioreactor for Manufacturing Chemotactically Competent Immune Cell Therapies | 2024 | Parijat Bhatnagar | SRI International |
| High-throughput, purification-free, and ultrasensitive transmembrane nanosensor arrays for digital counting of microRNA biomarkers of intact exosomes | 2023 | Hao Yan, Rizal Hariadi | Arizona State University - Tempe Campus |
| Multiplex In-Solution Protein Array (MISPA) for high throughput, quantitative, early profiling of pathogen-induced head and neck | 2023 | Joshua LaBaer | Arizona State University - Tempe Campus |
| Clonal analysis of cancer by mitochondrial DNA barcoding | 2023 | Peter Van Galen, Vijay Ganesh Sankaran | Brigham and Women's Hospital, Boston Children's Hospital |
| Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries | 2023 | Nir Hacohen | Broad Institute, Inc. |
| A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates | 2023 | Neel Shah | Columbia University New York Morningside |
| A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors | 2023 | Kathryn Meyer | Duke University |
| Micro-capsules for versatile multiplexed cytometry | 2023 | Allon Klein, Linas Mazutis | Harvard Medical School |
| Intersectional genetics-based biosensors for dormant cancer cells | 2023 | Jose Javier Bravo-Cordero | Icahn School of Medicine at Mount Sinai |
| Bioorthogonal probe development for highly parallel in vivo imaging | 2023 | Ralph Weissleder | Massachusetts General Hospital |
| MASTER Scaffolds for Rapid, Single-Step Manufacture and Prototyping of CAR-T cells | 2023 | Yevgeny Brudno | North Carolina State University Raleigh |
| A Novel Assay to Individualize Resensitization of Iodine-Refractory Thyroid Cancer | 2023 | Guillem Pratx | Stanford University |
| Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas | 2023 | Facundo Fernandez | Georgia Institute of Technology |
| Single cell modeling of cancer mutations | 2023 | Hanlee Ji | Stanford University |
| CoreView and FIBI for rapid-onsite evaluation and molecular profiling of core-needle breast biopsies | 2023 | Richard Levenson | University of California at Davis |
| Advanced development of composite gene delivery and CAR engineering systems | 2023 | Sidi Chen | Yale University |
| Program the Immune System against RAS-driven Cancer | 2023 | Xiaojing Gao, Monte Meier Winslow | Stanford University |
| Microfluidic technology to isolate tumoricidal T-cells from peripheral blood | 2023 | Venktesh Shirure | University of California at Davis |
| Rapid, simple, and ultrasensitive quantitation of KRAS ctDNA at the point of care using CRISPR/Cas amplification and digital resolution biosensor microscopy | 2023 | Brian Cunningham, Aaron Mansfield, Xing Wang | University of Illinois at Urbana-Champaign, Mayo Clinic Rochester |
| Integrated Imaging Tools for Intercellular Chemokine Signaling | 2023 | Gary Luker | University of Michigan at Ann Arbor |
| Engineering Protein Modulators of Notch Activation for T-cell Immunotherapy | 2023 | Joseph Muretta, Wendy Gordon | University of Minnesota |
| Combining Machine Learning and Nanofluidic Technology for the Multiplexed Diagnosis of Pancreatic Adenocarcinoma | 2023 | David Issadore, Erica Carpenter | University of Pennsylvania |
| Vesicle Epitope Transcript sequencing (VET-seq): Droplet-based Multiomic Profiling Platform for Single Vesicle Analysis | 2023 | Yue Lu | University of Utah |
| A novel multimodal ECM analysis platform for tumor characterization combining morphological and spectrochemical tissue imaging approaches | 2023 | Paul Campagnola, Filiz Yesilkoy | University of Wisconsin-Madison |
| Single-Molecule High-Confidence Detection of miRNA Cancer Biomarkers | 2023 | Soma Dhakal | Virginia Commonwealth University |
| A platform to identify in vivo targets of covalent cancer drugs in 3D tissues | 2023 | Li Ye, Benjamin Cravatt | The Scripps Research Institute |
| A Rapid and Comprehensive Approach for Clinical Genomic Profiling in Lung Cancer | 2023 | Eric Duncavage, David Spencer | Washington University |
| Plate reader assays to forensically assess exposure of plasma and serum to thawed conditions | 2022 | Chad Borges | Arizona State University - Tempe Campus |
| In-depth and label-free proteome profiling of hundreds of single cells per day | 2022 | Ryan Kelly | Brigham Young University |
| Adapting K-MDS to detect KRAS-mutant ctDNA | 2022 | Christopher Counter, James Abbruzzese | Duke University |
| Aliquot-level visual indicators of biospecimen exposure to thawed conditions | 2022 | Chad Borges | Arizona State University - Tempe Campus |
| Stitch-seq for genome-wide pooled genomic screening with RNA-seq readout | 2022 | Paul Blainey | Broad Institute, Inc. |
| Fluorescent gammaPNA Miniprobes for Imaging Telomeric RNA | 2022 | Bruce Armitage, Huaiying Zhang | Carnegie-Mellon University |
| A Practical Approach to Tumor-Specific Aptamers for B-Cell Hematologic Malignancies | 2022 | Qiao Lin | Columbia University New York Morningside |
| MousePaint: A massively combinatorial approach for illuminating tumor heterogeneity in True Color | 2022 | Joshua Snyder | Duke University |
| A low-cost, multiplexed digital high resolution melt platform for DNA methylation-based detection and identification of cancers in liquid biopsies | 2022 | Tza-Huei Jeff Wang, Thomas Pisanic II | Johns Hopkins University |
| 3D Fourier Imaging System for High Throughput Analyses of Cancer Organoids | 2022 | Hakho Lee | Massachusetts Institute of Technology |
| A cell-cycle induced genetic recorder for simultaneous recovery of cell divisions and lineage | 2022 | Ron Weiss, Carlo Maley | Massachusetts Institute of Technology, Arizona State University - Tempe Campus |
| Targeted Isolation and Identification of Sialylated Glycoproteins in Cancer Tissues, Cells, and Biofluids | 2022 | Richard Drake | Medical University of South Carolina |
| A CRISPR/Cas13 approach for identifying individual transcript isoform function in cancer | 2022 | David Knowles | New York Genome Center |
| Accessible high-throughput single-cell genome sequencing | 2022 | Andrew Adey | Oregon Health & Science University |
| A Novel Fluorescence Imaging Platform to Predict Response to Combinatorial Tyrosine Kinase Inhibitors | 2022 | Summer Gibbs | Oregon Health & Science University |
| Systematic characterization of cancer variants using single-cell functional genomics | 2022 | Thomas Norman, Scott Lowe | Sloan Kettering Institute Cancer Research |
| A micro-dissection platform for generating uniform-sized patient-derived tumor organoids (PDOs) for personalized cancer therapy | 2022 | Sindy Tang | Stanford University |
| Molecular and cellular imaging of bone biopsies using AI augmented deep UV Raman microscopy | 2022 | Vladislav Yakovlev, Mikhail Berezin | Texas Engineering Experiment Station, Washington University |
| Stimulated Brillouin Flow Cytometry for biomechanical assessment of metastatic potential | 2022 | Giuliano Scarcelli, Konstantinos Konstantopoulos, Stuart Martin | University of Maryland College Park, Johns Hopkins University, University of Maryland Baltimore |
| Microfluidic Precision Engineered Artificial Antigen Presenting Cells for Cancer Immunotherapy | 2022 | Abraham Lee, Anshu Agrawal | University of California-Irvine |
| A highly sensitive linear amplification based DNA methylation profiling technique for clinical cancer research | 2022 | Brian C-H Chiu, Wei Zhang | University of Chicago, Northwestern University |
| Transfer RNA sequencing and application to cancer research and clinics | 2022 | Tao Pan, Bruce Bissonnette, Benjamin Shogan | University of Chicago |
| Molecular Sub-typing Breast Cancer Patients using a Liquid Biopsy | 2022 | Steven Soper | University of Kansas Lawrence |
| Single-Cell Protein Activity Profiling in Breast Cancer Cells and Tissues | 2022 | Raymond Moellering | University of Chicago |
| Optogenetic Control of Tumor Initiation and Tumor Progression in vivo | 2022 | Andrei Karginov, Jalees Rehman | University of Illinois at Chicago |
| Advanced development and validation of an in vitro platform to phenotype brain metastatic tumor cells using artificial intelligence | 2022 | Sofia Merajver, Jianping Fu | University of Michigan at Ann Arbor |
| Enhanced mass-spectrometry-based approaches for in-depth profiling of the cancer extracellular matrix | 2022 | Alexandra Naba, Yu Gao | University of Illinois at Chicago |
| High-throughput inverted reporter assay for characterization of silencers and enhancer blockers | 2022 | Alan Boyle | University of Michigan at Ann Arbor |
| Photolithographic Tumor DNA Isolation | 2022 | Darryl Shibata | University of Southern California |
| A synthetic toolkit for the recombinant production of tyrosine phosphorylated proteins and peptides | 2022 | Kristen Naegle | University of Virginia |
| Efficient, cost-effective, and ultrasensitive sequencing of somatic mutations | 2022 | Stephen Salipante | University of Washington |
| Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic, and spatial phenotypes | 2022 | Dan Landau | Weill Medical Coll of Cornell University |
