| Quantification of molecular interactions across the matrix spectrum enables cancer research |
2024 |
Darryl Bornhop |
Vanderbilt University |
| A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis |
2024 |
Fei Chen |
Broad Institute |
| Bio-orthogonal Mid-infrared Photothermal Imaging of Cancer Metabolism |
2024 |
Ji-Xin Cheng |
Boston University |
| Spatial protein-protein interaction networks in situ by multiplexed proximity ligation |
2024 |
Ahmet Coskun |
Georgia Institute of Technology |
| Nano-CRISPR extracellular vesicle sensing system for longitudinal tumor monitoring |
2024 |
Hyungsoon Im |
Massachusetts General Hospital |
| Microphysiological platform for analyzing multiple myeloma's tumor microenvironment, enabling immunotherapy assessment and drug screening |
2024 |
Tania Tali Konry |
Northeastern University |
| Develop and validate demineralized bone paper-based human bone metabolic and senolytic assays |
2024 |
Jungwoo Lee |
University of Massachusetts Amherst |
| Precision Tumor Sampling of Melanoma Using Laser Microbiopsy |
2024 |
Sapun Parekh, James Tunnell |
University of Texas at Austin |
| 3D Proteomics at Single Cell Resolution with Covalent Protein Painting (CPP) |
2024 |
John Yates III |
Scripps Research Institute |
| Development of a Directed Evolution Platform for RNA Methyltransferases |
2024 |
Huiqing Zhou, Jia Niu |
Boston College |
| Multiplexed, Continuous Reporting of Gene Expression via CRISPR-mediated Transcriptional Activation |
2024 |
Jeffrey Ishizuka |
Yale University |
| Spatially resolved multi-omics sequencing of FFPE tissues at cellular level |
2024 |
Yanxiang Deng |
University of Pennsylvania |
| Evolved Molecules that Destroy Cancer Relevant Proteins |
2024 |
Elisa Biondi |
Foundation for Applied Molecular Evolution |
| A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state |
2024 |
Robert Rostomily,
Francois St-Pierre |
Methodist Hospital Research Institute, Baylor College of Medicine |
| Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq |
2024 |
Paul Blainey |
Broad Institute, Inc. |
| Quantitative analysis and manipulation of chromosome dynamics in cancer organoids |
2024 |
Torsten Wittmann |
University of California, San Francisco |
| Proximity epigenomics for context-specific analysis of complex chromatin features |
2024 |
Philipp Oberdoerffer |
Johns Hopkins University |
| Enabling in vivo barcoded single-cell multiomics-compatible genome-wide screens in personalized tumor models using defined-copy somatic transgenesis |
2024 |
Joshua Breunig |
Cedars-Sinai Medical Center |
| High Throughput Digital Droplet Assays for Ultrasensitive Multimodal (DNA, RNA, and Protein) Diagnostics |
2024 |
David Issadore |
University of Pennsylvania |
| An integrated functional proteomics platform for accelerated discovery of isoform-specific determinants of cancer |
2024 |
Gloria Sheynkman, Stephen Yi |
University of Virginia |
| Identification of cancer neoepitope-specific T cells using novel high-throughput hydrogel based platforms |
2024 |
Jonathan Schneck |
Johns Hopkins University |
| A Real-Time AI-Driven High-Throughput Proteomics Data Acquisition Method for Clinical Applications |
2024 |
Wilhelm Haas, Lecia Sequist |
Massachusetts General Hospital |
| New Chemical Tools for Covalent Drug Discovery |
2024 |
Jarrod Marto, Justin Kim |
Dana-Farber Cancer Institute |
| Tumor Metabolic Profiling by Multiplexed Single-Cell Lipid and mRNA Imaging |
2024 |
Sarah Heilshorn |
Stanford University |
| Bioreactor for Manufacturing Chemotactically Competent Immune Cell Therapies |
2024 |
Parijat Bhatnagar |
SRI International |
| High-throughput, purification-free, and ultrasensitive transmembrane nanosensor arrays for digital counting of microRNA biomarkers of intact exosomes |
2023 |
Hao Yan, Rizal Hariadi |
Arizona State University - Tempe Campus
|
| Multiplex In-Solution Protein Array (MISPA) for high throughput, quantitative, early profiling of pathogen-induced head and neck |
2023 |
Joshua LaBaer |
Arizona State University - Tempe Campus |
| Clonal analysis of cancer by mitochondrial DNA barcoding |
2023 |
Peter Van Galen, Vijay Ganesh Sankaran |
Brigham and Women's Hospital, Boston Children's Hospital |
| Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries |
2023 |
Nir Hacohen |
Broad Institute, Inc. |
| A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates |
2023 |
Neel Shah |
Columbia University New York Morningside |
| A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors |
2023 |
Kathryn Meyer |
Duke University |
| Micro-capsules for versatile multiplexed cytometry |
2023 |
Allon Klein, Linas Mazutis |
Harvard Medical School |
| Intersectional genetics-based biosensors for dormant cancer cells |
2023 |
Jose Javier Bravo-Cordero |
Icahn School of Medicine at Mount Sinai |
| Bioorthogonal probe development for highly parallel in vivo imaging |
2023 |
Ralph Weissleder |
Massachusetts General Hospital |
| MASTER Scaffolds for Rapid, Single-Step Manufacture and Prototyping of CAR-T cells |
2023 |
Yevgeny Brudno |
North Carolina State University Raleigh |
| A Novel Assay to Individualize Resensitization of Iodine-Refractory Thyroid Cancer |
2023 |
Guillem Pratx |
Stanford University |
| Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas |
2023 |
Facundo Fernandez |
Georgia Institute of Technology |
| Single cell modeling of cancer mutations |
2023 |
Hanlee Ji |
Stanford University |
| CoreView and FIBI for rapid-onsite evaluation and molecular profiling of core-needle breast biopsies |
2023 |
Richard Levenson |
University of California at Davis |
| Advanced development of composite gene delivery and CAR engineering systems |
2023 |
Sidi Chen |
Yale University |
| Program the Immune System against RAS-driven Cancer |
2023 |
Xiaojing Gao, Monte Meier Winslow |
Stanford University |
| Microfluidic technology to isolate tumoricidal T-cells from peripheral blood |
2023 |
Venktesh Shirure |
University of California at Davis |
| Rapid, simple, and ultrasensitive quantitation of KRAS ctDNA at the point of care using CRISPR/Cas amplification and digital resolution biosensor microscopy |
2023 |
Brian Cunningham, Aaron Mansfield, Xing Wang |
University of Illinois at Urbana-Champaign, Mayo Clinic Rochester |
| Integrated Imaging Tools for Intercellular Chemokine Signaling |
2023 |
Gary Luker |
University of Michigan at Ann Arbor |
| Engineering Protein Modulators of Notch Activation for T-cell Immunotherapy |
2023 |
Joseph Muretta, Wendy Gordon |
University of Minnesota |
| Combining Machine Learning and Nanofluidic Technology for the Multiplexed Diagnosis of Pancreatic Adenocarcinoma |
2023 |
David Issadore, Erica Carpenter |
University of Pennsylvania |
| Vesicle Epitope Transcript sequencing (VET-seq): Droplet-based Multiomic Profiling Platform for Single Vesicle Analysis |
2023 |
Yue Lu |
University of Utah |
| A novel multimodal ECM analysis platform for tumor characterization combining morphological and spectrochemical tissue imaging approaches |
2023 |
Paul Campagnola, Filiz Yesilkoy |
University of Wisconsin-Madison |
| Single-Molecule High-Confidence Detection of miRNA Cancer Biomarkers |
2023 |
Soma Dhakal |
Virginia Commonwealth University |
| A platform to identify in vivo targets of covalent cancer drugs in 3D tissues |
2023 |
Li Ye, Benjamin Cravatt |
The Scripps Research Institute |
| A Rapid and Comprehensive Approach for Clinical Genomic Profiling in Lung Cancer |
2023 |
Eric Duncavage, David Spencer |
Washington University |
| Plate reader assays to forensically assess exposure of plasma and serum to thawed conditions |
2022 |
Chad Borges |
Arizona State University - Tempe Campus |
| In-depth and label-free proteome profiling of hundreds of single cells per day |
2022 |
Ryan Kelly |
Brigham Young University |
| Adapting K-MDS to detect KRAS-mutant ctDNA |
2022 |
Christopher Counter, James Abbruzzese |
Duke University |
| Aliquot-level visual indicators of biospecimen exposure to thawed conditions |
2022 |
Chad Borges |
Arizona State University - Tempe Campus |
| Stitch-seq for genome-wide pooled genomic screening with RNA-seq readout |
2022 |
Paul Blainey |
Broad Institute, Inc. |
| Fluorescent gammaPNA Miniprobes for Imaging Telomeric RNA |
2022 |
Bruce Armitage, Huaiying Zhang |
Carnegie-Mellon University |
| A Practical Approach to Tumor-Specific Aptamers for B-Cell Hematologic Malignancies |
2022 |
Qiao Lin |
Columbia University New York Morningside |
| MousePaint: A massively combinatorial approach for illuminating tumor heterogeneity in True Color |
2022 |
Joshua Snyder |
Duke University |
| A low-cost, multiplexed digital high resolution melt platform for DNA methylation-based detection and identification of cancers in liquid biopsies |
2022 |
Tza-Huei Jeff Wang, Thomas Pisanic II |
Johns Hopkins University |
| 3D Fourier Imaging System for High Throughput Analyses of Cancer Organoids |
2022 |
Hakho Lee |
Massachusetts Institute of Technology |
| A cell-cycle induced genetic recorder for simultaneous recovery of cell divisions and lineage |
2022 |
Ron Weiss, Carlo Maley |
Massachusetts Institute of Technology, Arizona State University - Tempe Campus |
| Targeted Isolation and Identification of Sialylated Glycoproteins in Cancer Tissues, Cells, and Biofluids |
2022 |
Richard Drake |
Medical University of South Carolina |
| A CRISPR/Cas13 approach for identifying individual transcript isoform function in cancer |
2022 |
David Knowles |
New York Genome Center |
| Accessible high-throughput single-cell genome sequencing |
2022 |
Andrew Adey |
Oregon Health & Science University |
| A Novel Fluorescence Imaging Platform to Predict Response to Combinatorial Tyrosine Kinase Inhibitors |
2022 |
Summer Gibbs |
Oregon Health & Science University |
| Systematic characterization of cancer variants using single-cell functional genomics |
2022 |
Thomas Norman, Scott Lowe |
Sloan Kettering Institute Cancer Research |
| A micro-dissection platform for generating uniform-sized patient-derived tumor organoids (PDOs) for personalized cancer therapy |
2022 |
Sindy Tang |
Stanford University |
| Molecular and cellular imaging of bone biopsies using AI augmented deep UV Raman microscopy |
2022 |
Vladislav Yakovlev, Mikhail Berezin |
Texas Engineering Experiment Station, Washington University |
| Stimulated Brillouin Flow Cytometry for biomechanical assessment of metastatic potential |
2022 |
Giuliano Scarcelli, Konstantinos Konstantopoulos, Stuart Martin |
University of Maryland College Park, Johns Hopkins University, University of Maryland Baltimore |
| Microfluidic Precision Engineered Artificial Antigen Presenting Cells for Cancer Immunotherapy |
2022 |
Abraham Lee, Anshu Agrawal |
University of California-Irvine |
| A highly sensitive linear amplification based DNA methylation profiling technique for clinical cancer research |
2022 |
Brian C-H Chiu, Wei Zhang |
University of Chicago, Northwestern University |
| Transfer RNA sequencing and application to cancer research and clinics |
2022 |
Tao Pan, Bruce Bissonnette, Benjamin Shogan |
University of Chicago |
| Molecular Sub-typing Breast Cancer Patients using a Liquid Biopsy |
2022 |
Steven Soper |
University of Kansas Lawrence |
| Single-Cell Protein Activity Profiling in Breast Cancer Cells and Tissues |
2022 |
Raymond Moellering |
University of Chicago |
| Optogenetic Control of Tumor Initiation and Tumor Progression in vivo |
2022 |
Andrei Karginov, Jalees Rehman |
University of Illinois at Chicago |
| Advanced development and validation of an in vitro platform to phenotype brain metastatic tumor cells using artificial intelligence |
2022 |
Sofia Merajver, Jianping Fu |
University of Michigan at Ann Arbor |
| Enhanced mass-spectrometry-based approaches for in-depth profiling of the cancer extracellular matrix |
2022 |
Alexandra Naba, Yu Gao |
University of Illinois at Chicago |
| High-throughput inverted reporter assay for characterization of silencers and enhancer blockers |
2022 |
Alan Boyle |
University of Michigan at Ann Arbor |
| Photolithographic Tumor DNA Isolation |
2022 |
Darryl Shibata |
University of Southern California |
| A synthetic toolkit for the recombinant production of tyrosine phosphorylated proteins and peptides |
2022 |
Kristen Naegle |
University of Virginia |
| Efficient, cost-effective, and ultrasensitive sequencing of somatic mutations |
2022 |
Stephen Salipante |
University of Washington |
| Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic, and spatial phenotypes |
2022 |
Dan Landau |
Weill Medical Coll of Cornell University |
