Progress in Advancing Basic Cancer Research

The Division of Cancer Biology (DCB) supports important fundamental discoveries across the entire spectrum of cancer biology, from structural insights to mechanisms of metastasis, which lay the foundation for advances in cancer prevention and treatment. The division also fosters emerging scientific areas and a diverse cancer research workforce to sustain continual opportunities and progress in basic cancer research.

DCB identifies, enables, and promotes impactful basic cancer biology research by supporting a diverse and vibrant community towards the advancement of fundamental knowledge and insights that, ultimately, provide a foundation for better health and well-being for patients and their advocates.

Advances in Cancer Biology Research

Examples of discoveries in cancer biology from DCB funded research projects in fiscal year 2023.
A Timeline of the Division of Cancer Biology Milestones

A list of DCB activities over time that contributed to progress in basic cancer research.
Meet the Division of Cancer Biology Investigators

DCB supports basic cancer researchers who are advancing our fundamental understanding of cancer. Investigators share their stories about the importance of cancer biology research.
Fundamental Research Paved the Way for the Development of Vorasidenib

This narrative traces back the fundamental cancer biology research involved in the development of Vorasidenib, a new promising clinical treatment for IDH-mutant low-grade gliomas.

FY23 DCB Progress in Advancing Basic Cancer Research

The FY23 Division of Cancer Biology (DCB) Progress in Advancing Basic Cancer Research infographic shows that DCB enables basic cancer biology studies and collaboration and supports basic cancer researchers, including new and early-stage investigators (ESIs). It also includes icons showing that DCB supports emerging areas and technological development in cancer biology. — View and Print Infographic

Examples of DCB Research to Achieve the Goals of the National Cancer Plan

Prevent Cancer

Understanding early events in the development of cancers
Detect Cancers Early

Developing preclinical approaches for the early detection of precancers and tumors
Develop Effective Treatments

Enhancing the discovery of interactions in the tumor ecosystem
Eliminate Inequities

Investigating mechanisms of disparate outcomes in cancer
Deliver Optimal Care

Using computational modeling to improve the design of therapies and clinical trials
Engage Every Person

Engaging advocates in the basic cancer research continuum
Maximize Data Utility

Using systems approaches to advance the understanding of cancer dynamics
Optimize the Workforce

Supporting the basic cancer research workforce