DCB Research Resources
GM/CA X-ray Beamline
NCI partnered with the National Institute of General Medical Sciences (NIGMS) to fund the construction and management of a state-of-the-art macromolecular crystallography synchrotron beamline for determining structures of biologically important macromolecules. The beamline, GM/CA CAT, is located at the Advanced Photon Source on the grounds of Argonne National Lab just outside of Chicago.
NCI has a significant amount of beamtime dedicated for the use of its grantees. Investigators interested in taking experiments to this facility should contact the beamline directly or email Dr. J. Randy Knowlton for additional information.
Chernobyl Tissue Bank (CTB)
DCB supports and manages biospecimen resources that collect, store, process, and disseminate human biological specimens (biospecimens) and associated data set for research on human cancer biology. The Chernobyl Tissue Bank is an international collaborative project that is supported by NCI and another global partner, with active participation from Russia and Ukraine, two countries heavily affected by the 1986 Chernobyl accident. The objective of the CTB is to establish and maintain a research resource that supports studies on the biology of thyroid cancer, the major health consequence of the Chernobyl accident.
For more information on this Tissue Bank, please visit the Chernobyl Tissue Bank website.
The International Registry of Werner Syndrome
The International Registry of Werner Syndrome is the primary repository of samples and data from patients with Werner Syndrome (WS), and was established in 1988 as part of an objective to positionally clone the WS gene.
The registry ascertains and genotypes new pedigree cases from around the world, using lymphoblastoids and/or fibroblasts from human research participants, and provides genetic confirmation of classical WS. It also establishes and cryopreserves cell lines and other material from these pedigrees (both affected patients and their clinically unaffected siblings), including Epstein-Barr transformed peripheral blood B lymphocytes, primary skin fibroblasts, immortalized skin fibroblasts, WRN cDNA constructs, and others. All these materials are available for research.
For more information on this Registry, please visit the Werner Syndrome Registry website.
NIH MHC Tetramer Program
This core facility provides custom synthesis and distribution of soluble MHC-peptide tetramer reagents that can be used to stain antigen-specific T cells. The facility is supported by a contract from the National Institute of Allergy and Infectious Diseases, with steering committee participation from NCI through DCB.
For more information about this program, please visit the Emory University tetramer website.
New Grantee Workshop
DCB offers an annual workshop for new and early-stage investigators to familiarize them with the processes and standards of DCB, NCI and NIH.
The workshop is designed for DCB grantees who have received their first independent NIH grant within the last year. New grantees are identified by the Division, and attendance is by invitation only.
The workshop covers:
- Structure, roles, and inter-relationships of NIH, NCI, and DCB
- Branches within DCB
- NIH peer review process
- Competitive renewal applications
- Sources of supplemental funding
- Grantee responsibilities in managing their awards
The workshop includes breakout sessions with DCB Program Directors and a seminar from an NCI-funded senior cancer researcher.
Questions should be directed to Dr. Susan McCarthy.
PowerPoint presentations from the December 2016 Workshop (Posted with permission from each author; please do not use without consent):
- Introduction to the NIH Grants System and DCB
- NCI Budget Processes – How is Grant Funding Policy Made?
- Communicating with Your NCI Program Director: Understanding the Who, What, Why & How
- Post-Award Administration (Funding) of Your NCI Grant
- Awards to Support Trainees
- CRCHD: Cancer Health Disparities Research and Diversity Training Opportunities
- The Cooperative Human Tissue Network (CHTN): An NCI-Supported Biospecimen Open to the Scientific Community
- Additional DCB-Relevant Engagement and Funding Opportunities
- Understanding the Cancer Moonshot and Future Opportunities
- What’s Next on Your Grant Pathway?
Research Interest Group
Biomedical Citizen Science and Crowdsourcing: The NIH Citizen Science Working Group
This trans-NIH working group is investigating the usefulness and possible incorporation of citizen science methodologies into biomedical research in a way that maintains NIH’s high scientific and ethical standards.
Citizen science is a collaborative approach to research involving the public as direct collaborators and partners in the research process itself — not just as subjects of the research or advisors to the research. Citizen science takes many forms, and involves a variety of approaches benefiting from the creativity and problem-solving skills of the public and from citizen-collected data and insights not obtainable through conventional approaches.
This working group investigates, shares best practices, and engages in discussion with other agencies and groups promoting citizen science in other fields. The working group is composed of program officers, scientific review officers, and others from across NIH interested in furthering the adoption and incorporation of citizen science methodology into biomedical research.