NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,531 terms related to cancer and medicine.

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variant of unknown significance
(VAYR-ee-unt … UN-none sig-NIH-fih-kunts)
A change in a gene’s DNA sequence that has an unknown effect on a person’s health. There is usually not enough information about a variant of unknown significance to know whether it increases a person’s risk of developing a disease, such as cancer. Also called unclassified variant, variant of uncertain significance, and VUS.