NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,525 terms related to cancer and medicine.

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transient myeloproliferative disorder
(TRAN-zee-ent MY-eh-loh-proh-LIH-feh-ruh-tiv dis-OR-der)
A bone marrow disorder that can occur in newborns who have Down syndrome. It is marked by abnormal, immature blood-forming cells in the blood and bone marrow (especially the cells involved in making platelets). The liver may also be larger than normal. Transient myeloproliferative disorder is caused by mutations (changes) in a gene called GATA1. Transient myeloproliferative disorder usually goes away on its own within the first 3 months of life. Sometimes transient myeloproliferative disorder causes severe or life-threatening problems, such as bleeding problems, infection, heart, kidney, and liver failure, and abnormal build-up of fluid in the tissues that cover the organs in the body. Infants who have transient myeloproliferative disorder have an increased risk of developing acute myeloid leukemia (AML) before the age of 3 years. Also called TAM, TMD, transient abnormal myelopoiesis, and transient leukemia.