NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,442 terms related to cancer and medicine.

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NEDD8-activating enzyme inhibitor
(… AK-tih-vay-ting EN-zime in-HIH-bih-ter)
A substance that blocks an enzyme called NEDD8-activating enzyme (NAE). NAE is involved in important cell functions, such as cell division. Blocking NAE may help keep cancer cells from growing and may kill them. Some NEDD8-activating enzyme inhibitors are being studied in the treatment of cancer. They are a type of targeted therapy. Also called NAE inhibitor.