NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,573 terms related to cancer and medicine.

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umbrella trial
(um-BREH-luh TRY-ul)
A type of clinical trial that tests how well new drugs or other substances work in patients who have the same type of cancer but different gene mutations (changes) or biomarkers. In umbrella trials, patients receive treatment based on the specific mutation or biomarker found in their cancer. The drugs being tested may change during the trial, as new targets and drugs are found. Umbrella trials may allow new drugs to be tested and approved more quickly than traditional clinical trials.