NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,468 terms related to cancer and medicine.

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androgen receptor antagonist
(AN-droh-jen reh-SEP-ter an-TA-guh-nist)
A substance that keeps androgens (male sex hormones) from binding to proteins called androgen receptors, which are found in normal prostate cells, some prostate cancer cells, and in cells of some other tissues. Preventing this binding blocks the effects of these hormones in the body. Treatment with androgen receptor antagonists may keep prostate cancer cells from growing. Examples of androgen receptor antagonists used to treat prostate cancer are apalutamide, bicalutamide, enzalutamide, flutamide, and nilutamide. Also called androgen receptor blocker and antiandrogen.