NCI Dictionary of Cancer Terms
The NCI Dictionary of Cancer Terms features 8,359 terms related to cancer and medicine.
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- axicabtagene ciloleucel
- listen (AK-see-KAB-tuh-jeen sy-loh-LOO-sel)
A drug used to
treat certain types of large B-cell non-Hodgkin lymphoma
that relapsed (came back) or did not get better after
treatment with at least two other types of anticancer
therapy. It is also being studied in the treatment of other
types of cancer. Axicabtagene ciloleucel is
made using a patient’s T cells (a type of immune system
cell). A gene for a special receptor called chimeric
antigen receptor (CAR) is added to the T cells in the
laboratory. These changed T cells called CAR T cells are
grown in large numbers in the laboratory and given to the
patient by infusion. Axicabtagene ciloleucel
binds to a protein called CD19, which is found on most B
cell lymphoma cells. This helps the body’s immune system
kill cancer cells. Axicabtagene ciloleucel is
a type of CAR T-cell therapy. Also called Yescarta.