NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,468 terms related to cancer and medicine.

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c-erbB-2 positive
(… PAH-zih-tiv)
Describes cancer cells that have too much of a protein called HER2 on their surface. In normal cells, HER2 helps to control cell growth. When it is made in larger than normal amounts by cancer cells, the cells may grow more quickly and be more likely to spread to other parts of the body. Checking to see if a cancer is c-erbB-2 positive may help plan treatment, which may include drugs that kill c-erbB-2 positive cancer cells. Cancers that may be c-erbB-2 positive include breast, bladder, pancreatic, ovarian, and stomach cancers. Also called HER2 positive and human epidermal growth factor receptor 2 positive.