NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,547 terms related to cancer and medicine.

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chimeric antigen receptor T-cell therapy
(ky-MEER-ik AN-tih-jen reh-SEP-ter T-sel THAYR-uh-pee)
A type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion. Chimeric antigen receptor T-cell therapy is being studied in the treatment of some types of cancer. Also called CAR T-cell therapy.