NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,386 terms related to cancer and medicine.

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isocitrate dehydrogenase-2 gene
(I-soh-SIH-trayt dee-hy-DRAH-jeh-nays … jeen)
A gene that makes a protein called isocitrate dehydrogenase 2 (IDH2). This protein is found inside small structures in cells called mitochondria. The IDH2 protein helps the mitochondria make energy for many cell functions. Mutations (changes) in the isocitrate dehydrogenase-2 gene have been found in some types of cancer, including acute myelogenous leukemia (AML) and brain cancer, and in certain genetic conditions. These changes may cause cancer cells to grow and spread in the body. Also called IDH2 gene.