NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,545 terms related to cancer and medicine.

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A drug used with lenvatinib mesylate to treat certain types of endometrial cancer. It is also used with axitinib to treat certain types of renal cell carcinoma (a type of kidney cancer). Keytruda is also used alone or with other drugs to treat certain types of esophageal cancer, small cell lung cancer, Merkel cell carcinoma, hepatocellular carcinoma (a type of liver cancer), cervical cancer, stomach cancer, gastroesophageal junction cancer, urothelial carcinoma (a type of bladder cancer), Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, non-small cell lung cancer, head and neck cancer, and melanoma. It is also used to treat some types of solid tumors, including colorectal cancer, that have certain mutations in genes involved in DNA repair. It is also being studied in the treatment of other types of cancer. Keytruda binds to a protein called PD-1, which is found on T cells. Keytruda may block PD-1 and help the immune system kill cancer cells. It is a type of monoclonal antibody and a type of immune checkpoint inhibitor. Also called pembrolizumab.