NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,545 terms related to cancer and medicine.

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nivolumab
(nih-VOL-yoo-mab)
A drug used alone or with ipilimumab in adults and in children aged 12 years and older to treat a certain type of colorectal cancer that has mutations (changes) in genes involved in DNA repair. It is also used with ipilimumab in some patients to treat renal cell carcinoma (RCC), melanoma, and hepatocellular carcinoma (HCC). Nivolumab is also used alone in some patients to treat small cell lung cancer, non-small cell lung cancer, squamous cell carcinoma of the head and neck, classic Hodgkin lymphoma, melanoma, RCC, urothelial carcinoma, and HCC. It is also being studied in the treatment of other types of cancer. Nivolumab binds to a protein called PD-1, which is found on T cells (a type of white blood cell). Nivolumab may block PD-1 and help the immune system kill cancer cells. It is a type of monoclonal antibody and a type of immune checkpoint inhibitor. Also called Opdivo.