NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,545 terms related to cancer and medicine.

We offer a widget that you can add to your website to let users look up cancer-related terms. Get NCI’s Dictionary of Cancer Terms Widget.

p53 gene
(… jeen)
A gene that makes a protein called tumor protein p53. This protein is found inside the nucleus of cells and plays a key role in controlling cell division and cell death. It helps keep abnormal cells, including cancer cells, from growing. Mutations (changes) in the p53 gene may cause cancer cells to grow and spread in the body. These changes have been found in a genetic condition called Li-Fraumeni syndrome and in many types of cancer. The p53 gene is a type of tumor suppressor gene. Also called TP53 gene and tumor protein p53 gene.