NCI Dictionary of Cancer Terms
The NCI Dictionary of Cancer Terms features 8,470 terms related to cancer and medicine.
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- Sipple syndrome
- listen (SIH-pul SIN-drome)
genetic disorder that affects the endocrine glands and
causes a type of thyroid cancer called medullary thyroid
cancer, pheochromocytoma, and parathyroid gland cancer. It
may also cause benign (noncancerous) tumors in the
parathyroid glands and adrenal glands. The affected
endocrine glands may make high levels of hormones, which
can lead to other medical problems such as high blood
pressure and kidney stones. An itchy skin condition may
also occur. Sipple syndrome is caused
by a mutation (change) in a gene called
RET. Also called MEN2A, MEN2A syndrome, multiple endocrine adenomatosis type 2A, and multiple endocrine neoplasia type 2A syndrome.