NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,537 terms related to cancer and medicine.

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Zejula
(zeh-JOO-luh)
A drug used in adults to treat recurrent ovarian epithelial, fallopian tube, or primary peritoneal cancer that has gotten better after treatment with anticancer drugs that included platinum. It is used to help keep the cancer from coming back again. Zejula is also used in adults whose cancer is advanced, has already been treated with at least three other types of anticancer drugs, and has (1) certain mutations (changes) in the BRCA1 or BRCA2 gene or (2) genomic instability and has gotten worse after a response to treatment that included platinum. It is also being studied in the treatment of other types of cancer. Zejula blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. Zejula is a type of poly (ADP-ribose) polymerase inhibitor. Also called niraparib tosylate monohydrate.