NCI Dictionary of Cancer Terms

The NCI Dictionary of Cancer Terms features 8,463 terms related to cancer and medicine.

We offer a widget that you can add to your website to let users look up cancer-related terms. Get NCI’s Dictionary of Cancer Terms Widget.

Browse:
6 results found for: HER2
HER2
A protein involved in normal cell growth. HER2 may be made in larger than normal amounts by some types of cancer cells, including breast, ovarian, bladder, pancreatic, and stomach cancers. This may cause cancer cells to grow more quickly and spread to other parts of the body. Checking the amount of HER2 on some types of cancer cells may help plan treatment. Also called c-erbB-2, HER2/neu, human EGF receptor 2, and human epidermal growth factor receptor 2.
HER2 negative
(… NEH-guh-tiv)
Describes cancer cells that do not have a large amount of a protein called HER2 on their surface. In normal cells, HER2 helps to control cell growth. Cancer cells that are HER2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface. Checking for the amount of HER2 on some types of cancer cells may help plan treatment. These cancers include breast, bladder, ovarian, pancreatic, and stomach cancers. Also called human epidermal growth factor receptor 2 negative.
HER2 positive
(… PAH-zih-tiv)
Describes cancer cells that have too much of a protein called HER2 on their surface. In normal cells, HER2 helps to control cell growth. When it is made in larger than normal amounts by cancer cells, the cells may grow more quickly and be more likely to spread to other parts of the body. Checking to see if a cancer is HER2 positive may help plan treatment, which may include drugs that kill HER2 positive cancer cells. Cancers that may be HER2 positive include breast, bladder, pancreatic, ovarian, and stomach cancers. Also called c-erbB-2 positive and human epidermal growth factor receptor 2 positive.
HER2 test
A laboratory test that measures the amount of HER2 protein on cancer cells or how many copies of the HER2 gene are in the DNA of cancer cells. The HER2 protein helps control normal cell growth. Larger than normal amounts of the HER2 protein or too many copies of the HER2 gene may be made by some types of cancer, including breast, ovarian, bladder, pancreatic, and stomach cancers. This may cause cancer cells to grow more quickly and spread to other parts of the body. A HER2 test may be done to help plan treatment, which may include drugs that target the HER2 protein. It is a type of tumor marker test. Also called HER2/neu test and human epidermal growth factor receptor 2 test.
HER2/neu
A protein involved in normal cell growth. HER2/neu may be made in larger than normal amounts by some types of cancer cells, including breast, ovarian, bladder, pancreatic, and stomach cancers. This may cause cancer cells to grow more quickly and spread to other parts of the body. Checking the amount of HER2/neu on some types of cancer cells may help plan treatment. Also called c-erbB-2, HER2, human EGF receptor 2, and human epidermal growth factor receptor 2.
HER2/neu test
A laboratory test that measures the amount of HER2/neu protein on cancer cells or how many copies of the HER2/neu gene are in the DNA of cancer cells. The HER2/neu protein helps control normal cell growth. Larger than normal amounts of the HER2/neu protein or too many copies of the HER2/neu gene may be made by some types of cancer, including breast, ovarian, bladder, pancreatic, and stomach cancers. This may cause cancer cells to grow more quickly and spread to other parts of the body. A HER2/neu test may be done to help plan treatment, which may include drugs that target the HER2/neu protein. It is a type of tumor marker test. Also called HER2 test and human epidermal growth factor receptor 2 test.