NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 8,041 terms related to cancer and medicine.

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anti-platelet-derived growth factor receptor alpha monoclonal antibody IMC-3G3
(AN-tee-PLAYT-let-deh-RIVED grothe FAK-ter reh-SEP-ter AL-fuh MAH-noh-KLOH-nul AN-tee-BAH-dee …)
A drug used with doxorubicin to treat soft tissue sarcoma that cannot be treated with radiation therapy or surgery. It is used in patients whose cancer has not already been treated with an anthracycline (a type of anticancer drug). It is also being studied in the treatment of other types of cancer. Anti-platelet-derived growth factor receptor alpha monoclonal antibody IMC-3G3 binds to a receptor for a protein called platelet-derived growth factor (PDGF), which is found on some types of cancer cells. Blocking this protein receptor may help keep cancer cells from growing and prevent the growth of new blood vessels that tumors need to grow. Anti-platelet-derived growth factor receptor alpha monoclonal antibody IMC-3G3 is a type of monoclonal antibody. Also called anti-PDGFR alpha monoclonal antibody IMC-3G3, IMC-3G3, Lartruvo, and olaratumab.